GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7818688 | 1 | rs10093594 | chr8:96033236 | C8orf38 | chr8:95908040-96088396:+ | 0.15 | 3.56 | 0.000394 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs7818688 | 1 | rs10096455 | chr8:96041250 | C8orf38 | chr8:95908040-96088396:+ | -0.18 | -4.46 | 9.09E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs10097215 | 1 | rs10097215 | chr8:2506899 | CLN8 | chr8:1711870-1734735:+ | 0.24 | 4.18 | 3.14E-5 | Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) |
| BRCA | cis | rs7818688 | 1 | rs10098197 | chr8:96042890 | C8orf38 | chr8:95908040-96088396:+ | -0.18 | -4.47 | 8.83E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs7818688 | 1 | rs10098453 | chr8:96029756 | C8orf38 | chr8:95908040-96088396:+ | 0.14 | 3.38 | 0.000741 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs911119 | 1 | rs1010117 | chr20:23608421 | CST1 | chr20:23728191-23731574:- | 0.21 | 4.55 | 6.04E-6 | Chronic kidney disease |
| BRCA | cis | rs7818688 | 1 | rs10106491 | chr8:96038959 | C8orf38 | chr8:95908040-96088396:+ | -0.18 | -4.39 | 1.26E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs4493873 | 1 | rs10110267 | chr8:92073814 | LRRC69 | chr8:92114847-92231464:+ | -0.17 | -4.29 | 1.98E-5 | Migraine - clinic-based |
| BRCA | cis | rs11098499 | 1 | rs1011054 | chr4:120202387 | MAD2L1 | chr4:120980579-120988013:- | 0.08 | 3.51 | 0.000475 | Corneal astigmatism |
| BRCA | cis | rs13256369 | 1 | rs10110591 | chr8:8576608 | CLDN23 | chr8:8559666-8561616:+ | 0.16 | 4.09 | 4.72E-5 | Obesity-related traits |
| BRCA | cis | rs13256369 | 1 | rs10110591 | chr8:8576608 | ERI1 | chr8:8860314-8890849:+ | 0.17 | 4.38 | 1.3E-5 | Obesity-related traits |
| BRCA | cis | rs13256369 | 1 | rs10110591 | chr8:8576608 | PPP1R3B | chr8:8993774-9009084:- | 0.16 | 4.23 | 2.49E-5 | Obesity-related traits |
| BRCA | cis | rs13256369 | 1 | rs10110591 | chr8:8576608 | TNKS | chr8:9413445-9639855:+ | 0.13 | 3.89 | 0.000105 | Obesity-related traits |
| BRCA | cis | rs7818688 | 1 | rs10112230 | chr8:96038072 | C8orf38 | chr8:95908040-96088396:+ | -0.18 | -4.39 | 1.26E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs881375 | 1 | rs10117059 | chr9:123653477 | LOC253039 | chr9:123605320-123616644:+ | -0.36 | -10.03 | 1.12E-22 | Rheumatoid arthritis |